Autoimmune Disorders Panel

The Autoimmune Disorders Panel analyzes genes that are associated with autoinflammatory and autoimmune conditions. Autoinflammatory disorders are characterized by episodic inflammation due to inappropriate activation of the innate immune response, whereas autoimmune disorders are caused by defects in adaptive immunity leading to loss of self-tolerance. Autoimmune and autoinflammatory diseases share clinical manifestations including self-directed inflammation in the absence of a known trigger. Given the clinical overlap between these conditions, comprehensive testing enables a more efficient evaluation of multiple conditions based on a single indication for testing. This test may establish a genetic diagnosis, which would eliminate the need for serial gene testing. A genetic diagnosis may guide medical management, enabling a clinician to determine the need for additional evaluations, screenings, and procedures.